TY  - JOUR
PY  - 1983//
TI  - Profile of acute tolerance to three sedative anxiolytics
JO  - Psychopharmacology
A1  - Ellinwood, Everett H.
A1  - Linnoila, M.
A1  - Easler, M. E.
A1  - Molter, D. W.
SP  - 137
EP  - 141
VL  - 79
IS  - 2-3
N2  - Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.<p /> <p>Language: en</p> 
LA  - en
SN  - 0033-3158
UR  - http://dx.doi.org/
ID  - ref1
ER  -