TY  - JOUR
PY  - 2010//
TI  - A Systematic Review of the Incidence and Prevalence of Long-Term Neurological Conditions in the UK
JO  - Neuroepidemiology
A1  - Hoppitt, Thomas
A1  - Pall, Hardev
A1  - Calvert, Mel
A1  - Gill, Paramjit
A1  - Yao, Guiqing
A1  - Ramsay, Jill
A1  - James, Gill
A1  - Conduit, Jacky
A1  - Sackley, Cath
SP  - 19
EP  - 28
VL  - 36
IS  - 1
N2  - Background: Updated, robust estimates of the incidence and prevalence of rare long-term neurological conditions in the UK are not available. Global estimates may be misrepresentative as disease aetiology may vary by location. Objectives: To systematically review the incidence and prevalence of long-term neurological conditions in the UK since 1988. Search Strategy: Medline (January 1988 to January 2009), Embase (January 1988 to January 2009), CINAHL (January 1988 to January 2009) and Cochrane CENTRAL databases. Selection Criteria: UK population-based incidence/prevalence studies of long-term neurological conditions since 1988. Exclusion criteria included inappropriate diagnoses and incomprehensive case ascertainment. Data Collection and Analysis: Articles were included based on the selection criteria. Data were extracted from articles with ranges of incidence and prevalence reported. Main Results: Eight studies met the criteria (3 on motor neurone disease; 4 on Huntington's disease; 1 on progressive supranuclear palsy). The incidence of motor neurone disease ranged from 1.06 to 2.4/100,000 person-years. The prevalence ranged from 4.02 to 4.91/100,000. The prevalence of Huntington's disease ranged from 4.0 to 9.94/100,000. The prevalence of progressive supranuclear palsy ranged from 3.1 to 6.5/100,000. Conclusions: The review updates the incidence/prevalence of long-term neurological conditions. Future epidemiological studies must incorporate comprehensive case ascertainment methods and strict diagnostic criteria.<p />  <p>Language: en</p>
LA  - en
SN  - 0251-5350
UR  - http://dx.doi.org/10.1159/000321712
ID  - ref1
ER  -