TY  - JOUR
PY  - 2011//
TI  - Paracetamol orodispersible tablets: a risk for severe poisoning in children?
JO  - European journal of clinical pharmacology
A1  - Ceschi, Alessandro
A1  - Hofer, Katharina E.
A1  - Rauber-Lüthy, Christine
A1  - Kupferschmidt, Hugo
SP  - 97
EP  - 99
VL  - 67
IS  - 1
N2  - PURPOSE: Childhood paracetamol (acetaminophen) ingestion with subsequent risk of hepatotoxicity is a major medical problem. The aim of this study was to investigate the risk of high-dose ingestion of orodispersible, fast-disintegrating paracetamol tablets in children. METHODS: A retrospective single-center case study of all accidental selfadministrations of solid or orodispersible 500-mg paracetamol tablets occurring in children ≤ 6 years, reported to the Swiss Toxicological Information Centre between June 2003 and August 2009. RESULTS: We found 187 cases with ingestion of solid 500-mg paracetamol tablets and 16 cases with ingestion of orodispersible 500-mg tablets. The mean ingested dose in the orodispersible-tablet group was 59% higher than in the solid-tablet group (p = 0.085). Administration of activated charcoal and/or N-acetylcysteine because of ingestion of a potentially hepatotoxic paracetamol dose ( ≥ 150 mg/kg body weight) was recommended in 32 patients (17.1%) in the solid-tablet group and in five (31%) in the orodispersible-tablet group. CONCLUSIONS: Orodispersible paracetamol formulations may represent an important risk factor for severe paracetamol poisoning in children. Over-the-counter availability may contribute to increasing the use of this galenic formulation and eventually the number of poisonings in children.<p />  <p>Language: en</p>
LA  - en
SN  - 0031-6970
UR  - http://dx.doi.org/10.1007/s00228-010-0943-x
ID  - ref1
ER  -