TY  - JOUR
PY  - 2010//
TI  - Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function
JO  - Biomarkers in medicine
A1  - Teixeira, Antonio Lucio
A1  - Barbosa, Izabela Guimaraes
A1  - Diniz, Breno Satler
A1  - Kummer, Arthur
SP  - 871
EP  - 887
VL  - 4
IS  - 6
N2  - Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimer's disease, Huntington's disease and Parkinson's disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.<p />  <p>Language: en</p>
LA  - en
SN  - 1752-0363
UR  - http://dx.doi.org/10.2217/bmm.10.111
ID  - ref1
ER  -