TY  - JOUR
PY  - 2007//
TI  - Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago
JO  - Alcohol research and health
A1  - Moore, Shelley
A1  - Montane-Jaime, L. K.
A1  - Carr, Lucinda G.
A1  - Ehlers, Cindy L.
SP  - 28
EP  - 30
VL  - 30
IS  - 1
N2  - The population of Trinidad and Tobago is composed mainly of people of East Indian (Indo-Trinidadians) and African (Afro-Trinidadians) ancestry. Differences in alcoholism rates exist between these two ethnic groups, and researchers have investigated whether these differences can be explained in part by variations in the genes encoding the alcohol-metabolizing enzymes alcohol dehydrogenase (ADH) 1B and 1C, and aldehyde dehydrogenase (ALDH) 1 and 2. Studies have demonstrated that a certain variant of the gene encoding ADH1B (ADH1B*3) is associated with a reduced risk of alcoholism in Afro-Trinidadians, as is a variant of the gene encoding ADH1C (i.e., ADH1C*1) in Indo-Trinidadians. An ALDH2 variant shown to have protective effects primarily in East Asians was not found in either Trinidadian ethnic group. However, a variant in the gene encoding cytosolic ALDH1A (i.e. ALDH1A1*1/*2) was found to be associated with an increase in alcohol dependence in Indo-Trinidadians.<p /> <p>Language: en</p>
LA  - en
SN  - 1535-7414
UR  - http://dx.doi.org/
ID  - ref1
ER  -