TY  - JOUR
PY  - 2010//
TI  - Association between Tryptophan Hydroxylase 2 Gene Polymorphism and Completed Suicide
JO  - Suicide and life-threatening behavior
A1  - Fudalej, Sylwia
A1  - Ilgen, Mark
A1  - Fudalej, Marcin
A1  - Kostrzewa, Grażyna
A1  - Barry, Kristen
A1  - Wojnar, Marcin
A1  - Krajewski, Paweł
A1  - Blow, Frederic
A1  - Ploski, Rafal
SP  - 553
EP  - 560
VL  - 40
IS  - 6
N2  - The association between suicide and a single nucleotide polymorphism (rs1386483) was examined in the recently identified tryptophan hydroxylase 2 (TPH2) gene. Blood samples of 143 suicide victims and 162 age- and sex-matched controls were examined. The frequency of the TT genotype in the TPH2 polymorphism was higher in suicide victims than in controls (17.5% vs. 8.6%; p = 0.02), particularly in those with a history of repeated suicide attempts (53.3% vs. 8.6%; p < 0.0001). The examined TPH2 polymorphism was found to be associated with suicide. This genetic marker may be particularly important in understanding risk of multiple suicide attempts. Further analyses are needed to confirm these results.<p />  <p>Language: en</p>
LA  - en
SN  - 0363-0234
UR  - http://dx.doi.org/10.1521/suli.2010.40.6.553
ID  - ref1
ER  -