TY - JOUR PY - 1989// TI - Lactic acidosis in theophylline overdose JO - American journal of emergency medicine A1 - Leventhal, L. J. A1 - Kochar, G. A1 - Feldman, N. H. A1 - Podolsky, S. M. A1 - Stanek, M. S. SP - 417 EP - 418 VL - 7 IS - 4 N2 - An 18-year-old man with theophylline overdose developed an increased anion gap metabolic acidosis. Serum lactate levels were markedly elevated. A direct correlation was found between the increasing theophylline level, clinical hyperadrenergic state, and the worsening acidosis. Early hemoperfusion reversed the acidosis, the elevated serum theophylline level, and the hyperadrenergic state. This case substantiates the role of lactate accumulation in the metabolic acidosis associated with isolated theophylline toxicity.

Language: en

LA - en SN - 0735-6757 UR - http://dx.doi.org/ ID - ref1 ER -