TY  - JOUR
PY  - 2010//
TI  - Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity
JO  - American journal of medical genetics. part B, neuropsychiatric genetics
A1  - Benko, Anita
A1  - Lazary, Judit
A1  - Molnar, Eszter
A1  - Gonda, Xenia
A1  - Tothfalusi, Laszlo
A1  - Pap, Dorottya
A1  - Mirnics, Zsuzsanna
A1  - Kurimay, Tamas
A1  - Chase, Diana
A1  - Juhasz, Gabriella
A1  - Anderson, Ian M.
A1  - Deakin, John F. W.
A1  - Bagdy, Gyorgy
SP  - 592
EP  - 599
VL  - 153B
IS  - 2
N2  - Serotonin-1A (5-HT(1A)) receptors are known to play a role in impulsivity-related behavior. The C(-1019)G functional polymorphism (rs6295) has been suggested to regulate the 5-HT(1A) receptor gene (HTR(1A)) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuronal firing could be associated with the G allele. Previous studies indicate that this polymorphism is associated with aggression, suicide, and several psychiatric disorders, yet its association with impulsivity has rarely been investigated. We studied the relationship between impulsivity and the C(-1019)G polymorphism of the HTR(1A) in a population sample of 725 volunteers using the Impulsiveness subscale (IVE-I) of the Eysenck Impulsiveness, Venturesomeness, and Empathy scale and also the Barratt Impulsiveness Scale (BIS-11). Data were analyzed using analysis of variance with age and gender as covariates and Tukey's HSD post-hoc test. Post-hoc analysis revealed that the study had 0.958 power to detect 0.15 effect size. Significant differences between the C(-1019)G genotype groups (GG vs. GC vs. CC) were found. Subjects carrying GG genotype showed significantly higher impulsiveness scores compared to GC or CC carriers for the IVE-I scale (P = 0.014), for the Motor (P = 0.021), Cognitive Impulsiveness (P = 0.002), and for the BIS total score (P = 0.008) but not for the Nonplanning Impulsiveness (P = 0.520) subscale of the BIS-11. Our results suggest the involvement of the HTR(1A) in the continuum phenotype of impulsivity.<p />  <p>Language: en</p>
LA  - en
SN  - 1552-4841
UR  - http://dx.doi.org/10.1002/ajmg.b.31025
ID  - ref1
ER  -