TY  - JOUR
PY  - 1986//
TI  - Prediction of acetaminophen level from clinical history of overdose using a pharmacokinetic model
JO  - Annals of emergency medicine
A1  - Edwards, D. A.
A1  - Fish, S. F.
A1  - Lamson, M. J.
A1  - Lovejoy, F. H.
SP  - 1314
EP  - 1319
VL  - 15
IS  - 11
N2  - A retrospective study was undertaken to determine the accuracy of predicting acetaminophen levels using the pharmacokinetic equation for first-order absorption and elimination of a single oral ingestion, (Formula: see text) Forty-four acute adult acetaminophen overdoses were studied during a 22-month period. Eighty levels drawn from 0 to 16 hours after ingestion were evaluated. To standardize the data, only first levels drawn in patients without prior spontaneous or ipecac-induced vomiting were analyzed (n = 26). Of these 26 levels, eight (31%) were drawn from 0 to two hours after ingestion, eight (31%) from two to four hours, and ten (38%) from four to 16 hours, with correlations of 0.59, 0.85, and 0.98, respectively. To determine the accuracy of predicting four-hour levels, five patients with first levels drawn at four hours, prior to vomiting, were evaluated. Substituting appropriate constants, the condensed equation, Cp4h = (0.59) (mg/kg dose), was used to predict the four-hour level (r = 0.99). Preliminary data suggest the ability to accurately predict four-hour acetaminophen levels from ingestion history alone using pharmacokinetic equations.<p /> <p>Language: en</p>
LA  - en
SN  - 0196-0644
UR  - http://dx.doi.org/
ID  - ref1
ER  -