TY  - JOUR
PY  - 2003//
TI  - Suicide risk in bipolar patients: the role of co-morbid substance use disorders
JO  - Bipolar disorders
A1  - Dalton, E. Jane
A1  - Cate-Carter, Tasha D.
A1  - Mundo, Emanuela
A1  - Parikh, Sagar V.
A1  - Kennedy, James L.
SP  - 58
EP  - 61
VL  - 5
IS  - 1
N2  - OBJECTIVE: Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim of this study was to identify clinical predictors of suicide attempts in subjects with bipolar disorder. METHODS: We studied 336 subjects with a diagnosis of bipolar I, bipolar II, or schizoaffective disorder (bipolar type). The Structured Clinical Interview for DSM-IV (SCID-I) was administered and subsequently two expert psychiatrists established a diagnosis. Predictors of suicide attempts were examined in attempters and non-attempters. RESULTS: The lifetime rate of suicide attempts for the entire sample was 25.6%. A lifetime co-morbid substance use disorder was a significant predictor of suicide attempts: bipolar subjects with co-morbid substance use disorders (SUD) had a 39.5% lifetime rate of attempted suicide, while those without had a 23.8% rate (odds ratio = 2.09, 95% CI = 1.03-4.21, chi2 = 4.33, df = 1, p = 0.037). CONCLUSIONS: Lifetime co-morbid SUD were associated with a higher rate of suicide attempts in patients with bipolar disorder. This relationship may have a genetic origin and/or be explained by severity of illness and trait impulsivity.<p /> <p>Language: en</p>
LA  - en
SN  - 1398-5647
UR  - http://dx.doi.org/
ID  - ref1
ER  -