TY  - JOUR
PY  - 1999//
TI  - Active monitoring of 12,760 clozapine recipients in the UK and Ireland. Beyond pharmacovigilance
JO  - British journal of psychiatry
A1  - Munro, J.
A1  - O'Sullivan, D.
A1  - Andrews, C.
A1  - Arana, A.
A1  - Mortimer, A.
A1  - Kerwin, R.
SP  - 576
EP  - 580
VL  - 175
IS  - 
N2  - BACKGROUND: People prescribed clozapine for treatment-resistant schizophrenia have mandatory haematological monitoring through a case register for identifying reversible neutropenia. AIMS: To quantify risk factors for agranulocytosis in subjects receiving clozapine. METHOD: Data from 12,760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis. RESULTS: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P = 0.03). There was an age-related increase in risk of 53% per decade (P = 0.0001). CONCLUSIONS: The case register yielded valuable information for guiding research into the causes of the haematological reactions.<p /> <p>Language: en</p>
LA  - en
SN  - 0007-1250
UR  - http://dx.doi.org/
ID  - ref1
ER  -