TY  - JOUR
PY  - 1997//
TI  - Fatal overdose of clozapine
JO  - Forensic science international
A1  - Keller, T.
A1  - Miki, A.
A1  - Binda, S.
A1  - Dirnhofer, R.
SP  - 119
EP  - 125
VL  - 86
IS  - 1-2
N2  - An ingestion of an unknown quantity of Leponex (clozapine) tablets in a suicide is described. Although clozapine is known for over 30 years now, relatively few cases of intoxications due to clozapine overdose have been reported. The authors report a new and quick method to analyze and determine the clozapine and N-desmethylclozapine concentration in body fluids. The analytes and an internal standard (zolpidem) were extracted from alkalinized samples into ethyl acetate before GC/NPD analysis. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the neuroleptic drug Leponex.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/
ID  - ref1
ER  -