TY  - JOUR
PY  - 2011//
TI  - Neurobehavioral Effects of Acute Exposure to Normal (n-) Paraffins
JO  - International journal of toxicology
A1  - Lammers, Jan
A1  - Muijser, Hans
A1  - Owen, David
A1  - Kulig, Beverly
A1  - McKee, Richard
SP  - 47
EP  - 58
VL  - 30
IS  - 1
N2  - This article reports the results of neurobehavioral tests on C(5)-C(10) normal paraffinic constituents (n-paraffins). Shortly after exposure, effects were evaluated in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. The representative C(5) n-paraffin, n-pentane, did not produce any evidence of acute central nervous system (CNS) effects at levels up to 20 000 mg/m(3). Similarly, there was no compelling evidence that n-octane (C(8)) produced CNS effects at 14 000 mg/m(3), the highest concentration tested. n-decane (C(10)) produced minor, reversible acute CNS effects at 5000 mg/m(3), with 1500 mg/m(3) as the no-effect level. Consistent with literature data, there seemed to be a relationship between increasing molecular weight up to C(10) and acute CNS effects. However, the CNS effects were reversible. Repeated exposures did not provide evidence of metabolic induction.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-5818
UR  - http://dx.doi.org/10.1177/1091581810385148
ID  - ref1
ER  -