TY  - JOUR
PY  - 2008//
TI  - Determination of metaldehyde in human serum by headspace solid-phase microextraction and gas chromatography-mass spectrometry
JO  - Journal of chromatography B: analytical technologies in the biomedical and life sciences
A1  - Saito, Takeshi
A1  - Morita, Seiji
A1  - Motojyuku, Megumi
A1  - Akieda, Kazuki
A1  - Otsuka, Hiroyuki
A1  - Yamamoto, Isotoshi
A1  - Inokuchi, Sadaki
SP  - 573
EP  - 576
VL  - 875
IS  - 2
N2  - A rapid headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) method has been developed for the determination of metaldehyde in human serum samples. Metaldehyde is extensively used as a molluscicide for the control of slugs and snails, and cases of metaldehyde poisoning have been reported. Metaldehyde was headspace-extracted on a polydimethylsiloxane (PDMS) fiber at 70 degrees C for 25 min, desorbed, and analyzed rapidly by GC-MS. The method was validated for limit of detection (LOD), linearity, precision, and recovery. Although the recovery of the sample was very low, the method itself was rapid with a low detection limit of 0.25 microg/ml, R.S.D. value 12.6%, and linearity range 0.5-25.0 microg/ml (r(2)=0.999). The results demonstrated that the SPME-GC-MS method for the analysis of metaldehyde is simple, rapid, solvent-free, and does not require any pre-analysis conversions.<p /> <p>Language: en</p>
LA  - en
SN  - 1570-0232
UR  - http://dx.doi.org/10.1016/j.jchromb.2008.10.002
ID  - ref1
ER  -