TY  - JOUR
PY  - 1999//
TI  - Hydroxychloroquine overdose: toxicokinetics and management
JO  - Journal of toxicology - clinical toxicology
A1  - Jordan, P.
A1  - Brookes, J. G.
A1  - Nikolic, G.
A1  - Le Couteur, David G.
SP  - 861
EP  - 864
VL  - 37
IS  - 7
N2  - BACKGROUND: The management and toxicokinetics of hydroxychloroquine overdose are poorly described. CASE REPORT: We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Plasma hydroxychloroquine level was 29.40 mumol/L (9.87 mg/L) 2 hours after ingestion and the elimination half-life of hydroxychloroquine was 22 hours. CONCLUSIONS: The clinical manifestations of this hydroxychloroquine overdose were similar to those reported for chloroquine overdose and the management principles recommended for chloroquine overdose appeared to be efficacious in this case.<p /> <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/
ID  - ref1
ER  -