TY  - JOUR
PY  - 1990//
TI  - Psychiatric findings in Wolfram syndrome homozygotes
JO  - Lancet
A1  - Swift, R. G.
A1  - Sadler, D. B.
A1  - Swift, M.
SP  - 667
EP  - 669
VL  - 336
IS  - 8716
N2  - Diabetes mellitus and bilateral optic atrophy are the defining characteristics of the autosomal recessive Wolfram syndrome. Diabetes insipidus, neurogenic bladder, deafness, and other neurological manifestations are frequent. A review was made of the medical records of 68 Wolfram syndrome patients, aged between 8 and 43 years, identified by casefinding throughout the USA. 41 of the patients (60%) had episodes of severe depression, psychosis, or organic brain syndrome, as well as impulsive verbal and physical aggression. These symptoms were very severe in 17 patients (25%), of whom 12 required admission to a psychiatric hospital and 11 attempted suicide. We conclude that the Wolfram syndrome gene predisposes homozygotes to psychiatric illness.<p /> <p>Language: en</p>
LA  - en
SN  - 0140-6736
UR  - http://dx.doi.org/
ID  - ref1
ER  -