TY  - JOUR
PY  - 1997//
TI  - Protein kinase C in the postmortem brain of teenage suicide victims
JO  - Neuroscience letters
A1  - Pandey, Ganshayam N.
A1  - Dwivedi, Y.
A1  - Pandey, S. C.
A1  - Conley, R. R.
A1  - Roberts, R. C.
A1  - Tamminga, C. A.
SP  - 111
EP  - 114
VL  - 228
IS  - 2
N2  - Increased serotonin2A (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that Bmax of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.<p /> <p>Language: en</p>
LA  - en
SN  - 0304-3940
UR  - http://dx.doi.org/
ID  - ref1
ER  -