TY  - JOUR
PY  - 2008//
TI  - SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population
JO  - Progress in neuro-psychopharmacology and biological psychiatry
A1  - Wang, Yang
A1  - Zhang, Jing
A1  - Li, Xingwang
A1  - Ji, Jue
A1  - Yang, Fengping
A1  - Wan, Chunling
A1  - Feng, Guoyin
A1  - Wan, Peng
A1  - He, Lin
A1  - He, Guang
SP  - 1902
EP  - 1904
VL  - 32
IS  - 8
N2  - BACKGROUND: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD. METHODS: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin. RESULTS: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. CONCLUSION: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.<p /> <p>Language: en</p>
LA  - en
SN  - 0278-5846
UR  - http://dx.doi.org/10.1016/j.pnpbp.2008.09.003
ID  - ref1
ER  -