TY  - JOUR
PY  - 1984//
TI  - Report of experiences in the treatment of 16 cases of severe glycoside poisoning with digitalis antibody fragments (Fab)
JO  - Zeitschrift für Kardiologie
A1  - Smolarz, A.
A1  - Roesch, E.
A1  - Lenz, Helge
A1  - Neubert, P.
A1  - Abshagen, U.
SP  - 113
EP  - 119
VL  - 73
IS  - 2
N2  - To date, 16 patients with severe glycoside poisoning have been treated with Fab as part of the clinical trial for efficacy and tolerance. The ages of the patients ranged from 4 to 77 years. In 13 cases, the substance was taken with suicidal intent. The following were considered to be indications for the use of Fab: the appearance of life-threatening arrhythmias as high-grade atrioventricular conduction disorders, multifocal ectopic beats, ventricular tachycardia, and relapsing ventricular fibrillation in 5 cases. Serum digoxin concentrations were between 3.8 and 78 ng/ml before the start of treatment. The amount of Fab administered was 240-800 mg, in the majority of cases 480 mg. Regression of the arrhythmias was seen in all patients during or shortly after the Fab infusion. There was a rapid fall in the free digoxin in the serum to levels that were no longer measurable and a marked rise in bound digoxin with a simultaneous intensive excretion of bound digoxin in the urine. Fab therapy is considered to be a major advance in the treatment of severe, previously fatal, glycoside poisoning. No notable side effects were observed, nor were there any allergic reactions to foreign protein.<p /> <p>Language: de</p>
LA  - de
SN  - 0300-5860
UR  - http://dx.doi.org/
ID  - ref1
ER  -