TY  - JOUR
PY  - 2011//
TI  - Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy
JO  - Seizure
A1  - Machado, René Andrade
A1  - Espinosa, Arlety Garcia
A1  - Melendrez, Daliván
A1  - González, Yamila Remón
A1  - García, Víctor Frades
A1  - Rodríguez, Yaima Quintana
SP  - 280
EP  - 284
VL  - 20
IS  - 4
N2  - OBJECTIVE: To determine whether antiepileptic drugs constitute in themselves an independent risk factor for suicidality in patients with epilepsy. METHODS: One hundred and thirty one patients with epilepsy were recruited and followed-up during 5 years. A detailed medical history, neurological examination, EEGs, Mini-International Neuropsychiatric Interview, executive function, and MRI were assessed. Systematically collected data were used to assess suicidality. Multiple regression analysis was carried out to examine predictive associations between clinical variables, psychiatric disorders, antiepileptic drugs and suicidality. RESULTS: We identified two AEDs related with suicide attempts (PHB and LTG) and four with suicidal risk: PHB, PRM, PHT and LTG, but the increased of risk diminished or disappeared when psychiatric comorbidity and other well established risk factors for suicidality were analyzed. We found a significant proportion of patients with depressive episodes associated with Topiramate, Phenitoin, Phenobarbital and Lamotrigine. CONCLUSION: Antiepileptic drugs probably do not have an impact on suicidality.<p />  <p>Language: en</p>
LA  - en
SN  - 1059-1311
UR  - http://dx.doi.org/10.1016/j.seizure.2010.12.010
ID  - ref1
ER  -