TY  - JOUR
PY  - 2011//
TI  - Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
JO  - Comprehensive psychiatry
A1  - Reti, Irving M.
A1  - Xu, Jerry Z.
A1  - Yanofski, Jason
A1  - McKibben, Jodi
A1  - Uhart, Magdalena
A1  - Cheng, Yu-Jen
A1  - Zandi, Peter
A1  - Bienvenu, Oscar J.
A1  - Samuels, Jack
A1  - Willour, Virginia
A1  - Kasch-Semenza, Laura
A1  - Costa, Paul
A1  - Bandeen-Roche, Karen
A1  - Eaton, William W.
A1  - Nestadt, Gerald
SP  - 188
EP  - 194
VL  - 52
IS  - 2
N2  - OBJECTIVE: Preclinical and human family studies clearly link monoamine oxidase A (MAOA) to aggression and antisocial personality (ASP). The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear. METHODS: We evaluated the association of the variable number tandem repeat of the MAOA promoter with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ASP disorder (ASPD) traits in a community sample of 435 participants from the Hopkins Epidemiology of Personality Disorders Study. RESULTS: We did not find an association between the activity of the MAOA allele and ASPD traits; however, among whites, when subjects with a history of childhood physical abuse were excluded, the remaining subjects with low-activity alleles had ASPD trait counts that were 41% greater than those with high-activity alleles (P < .05). CONCLUSION: The high-activity MAOA allele is protective against ASP among whites with no history of physical abuse, lending support to a link between MAOA expression and antisocial behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0010-440X
UR  - http://dx.doi.org/10.1016/j.comppsych.2010.05.005
ID  - ref1
ER  -