TY  - JOUR
PY  - 1989//
TI  - Reversal sign on CT: effect of anoxic/ischemic cerebral injury in children
JO  - AJNR. American journal of neuroradiology
A1  - Han, B. K.
A1  - Towbin, R. B.
A1  - De Courten-Myers, G.
A1  - McLaurin, R. L.
A1  - Ball, W. S.
SP  - 1191
EP  - 1198
VL  - 10
IS  - 6
N2  - A retrospective study was performed to determine the clinical and pathologic features, etiology, and outcome of children with the reversal sign. The reversal sign, a striking CT finding, probably represents a diffuse, anoxic/ischemic cerebral injury. CT features of the reversal sign are diffusely decreased density of cerebral cortical gray and white matter with a decreased or lost gray/white matter interface, or reversal of the gray/white matter densities and relatively increased density of the thalami, brainstem, and cerebellum. Twenty children with the reversal sign were retrospectively analyzed. We divided the patients into three groups: (1) acute reversal, (2) intermediate group, and (3) chronic reversal. There were nine cases of trauma (seven of child abuse); nine hypoxia/anoxia incidents (birth asphyxia, drowning, status epilepticus); one bacterial meningitis; and one degenerative encephalitis. All acute- and intermediate-group patients had respiratory problems requiring ventilator support and intensive care. In five of seven patients who died, autopsy findings were consistent with anoxic/ischemic encephalopathy. Surviving patients have profound neurologic deficits with severe developmental delay. The CT reversal sign carries a poor prognosis and indicates irreversible brain damage.<p /> <p>Language: en</p>
LA  - en
SN  - 0195-6108
UR  - http://dx.doi.org/
ID  - ref1
ER  -