TY  - JOUR
PY  - 2006//
TI  - Central nervous system pseudallescheriasis after near-drowning
JO  - Clinical neurology and neurosurgery
A1  - Panichpisal, Kessarin
A1  - Nugent, Kenneth
A1  - Sarria, Juan C.
SP  - 348
EP  - 352
VL  - 108
IS  - 4
N2  - BACKGROUND: Clinical characteristics of central nervous system (CNS) pseudallescheriasis after near-drowning have not been systematically analyzed. METHODS: Review of cases reported in the English-language literature. RESULTS: Sixteen patients were identified. The average period between the near-drowning episode and onset of clinical manifestations was 37 days. Common manifestations included fever, altered mental status, headache, seizures, and hemiparesis. All patients developed brain abscesses; however, imaging studies were normal at presentation in 6 patients. Cerebrospinal fluid neutrophilic pleocytosis, elevated protein, and decreased glucose were commonly observed. Most patients were treated with surgical resection and systemic amphotericin B or miconazole. Voriconazole was used in 2 patients. Twelve patients (75%) died. The average time between the near-drowning episode and death was 12 weeks. Four survivors received prompt treatment. CONCLUSIONS: CNS pseudallescheriasis after near-drowning is highly lethal. Early diagnosis and aggressive medical and surgical interventions may improve survival.<p /> <p>Language: en</p>
LA  - en
SN  - 0303-8467
UR  - http://dx.doi.org/10.1016/j.clineuro.2005.10.013
ID  - ref1
ER  -