TY  - JOUR
PY  - 1983//
TI  - Ultrastructural pathology of the alveolar apparatus in experimental drowning
JO  - Zeitschrift fur Rechtsmedizin
A1  - Brinkmann, B.
A1  - Fechner, G.
A1  - Puschel, K.
SP  - 47
EP  - 60
VL  - 91
IS  - 1
N2  - Investigations were carried out on anaesthetized rats which by a tracheotomy tube actively aspirated liquids of different osmolarities covering a range from tap water to 2.9% NaCl solution. In every range of osmolarity, the ultrastructural alterations show areolar limitations and different stages of development. In freshwater the influx of liquid causes a hypoxemic-dysoric alveolose with diffuse of pulvinate oedematous swellings of all compartments of the blood-gas-barrier, cytolysis, karyolysis, membrane desintegration, hydropic alterations of the (cell) organelles, dilatation of the drainage tracts of the alveolar interstitium. Vesicular transformation caused by a dilatation of the pinocytotic system ending in endothelial and epithelial vesiculation. Salt-water drowning leads to a hypoxemic alveolose with a marked compaction of the matrix. The epithelium shows many alterations of the surface, numerous protrusions, constrictions and expose of the basement membrane (villous transformation). Erythrocyte sludge and thorn-apple-shaped erythrocytes are found in the capillaries. Application of electron microscopy in the diagnosis of drowning allows a more reliable classification and, correspondingly, decisive improvements of the reliability of lightmicroscopical findings.<p /> <p>Language: de</p>
LA  - de
SN  - 0044-3433
UR  - http://dx.doi.org/
ID  - ref1
ER  -