TY  - JOUR
PY  - 1997//
TI  - Psychomotor performance during initial stage of exposure to halothane, enflurane, isoflurane and sevoflurane in mice
JO  - Clinical and experimental pharmacology and physiology
A1  - Komatsu, H.
A1  - Nogaya, J.
A1  - Kuratani, N.
A1  - Ueki, M.
A1  - Yokono, S.
A1  - Ogli, K.
SP  - 706
EP  - 709
VL  - 24
IS  - 9-10
N2  - 1. The dose-response relationship during the pre-anaesthetic and pre-equilibrium state of four inhalation anaesthetics (halothane, enflurane, isoflurane and sevoflurane) on fixed-ratio schedule-controlled behaviour was studied in mice. 2. Animals exposed to halothane, enflurane and isoflurane showed a biphasic pattern (i.e. a significant incremental increase in psychomotor responses at low inspired concentrations (0.1-0.4%) and decrements at greater concentrations) in a dose-dependent manner. Mean peak responses (per cent of control) were 132.3 (P < 0.01 vs control), 124.0 (P < 0.05) and 116.7% (P < 0.05) at 0.1% halothane, 0.3% enflurane and 0.2% isoflurane, respectively. 3. Sevoflurane did not increase schedule-controlled behavioural responses at any concentration. 4. The effect of subanaesthetic concentrations of inhalation anaesthetics on psychomotor performance can be evaluated as changes in the response rate in schedule-controlled behaviour.<p /> <p>Language: en</p>
LA  - en
SN  - 0305-1870
UR  - http://dx.doi.org/
ID  - ref1
ER  -