TY  - JOUR
PY  - 1997//
TI  - Common association of HPV 2 with anogenital warts in prepubertal children
JO  - Pediatric dermatology
A1  - Handley, J.
A1  - Hanks, E.
A1  - Armstrong, K.
A1  - Bingham, A.
A1  - Dinsmore, W.
A1  - Swann, A.
A1  - Evans, M. F.
A1  - McGee, J. O.
A1  - O'Leary, J.
SP  - 339
EP  - 343
VL  - 14
IS  - 5
N2  - Anogenital (AG) warts in 31 prepubertal children were HPV typed by nonisotopic in situ hybridization (NISH) using digoxigenin-labeled probes for human papilloma virus (HPV) types 1-5, 6, 11, 16, 18, 31, and 33. Mode of transmission was determined from historical, clinical, and laboratory data independent of HPV typing. HPV 2 was detected most commonly (13/31 warts) followed by HPV 6 (7/31), HPV 11 (5/31), and HPV 16 (1/31). Although not reaching statistical significance, our results suggested that a mucosal HPV type (6, 11, 16) in a child's AG warts implied transmission from mucosal warts and conversely cutaneous HPV 2 transmission from warts at a cutaneous site. HPV typing provided no helpful information regarding actual mode of transmission of AG warts in these children. The high prevalence of HPV 2 in children's AG warts and the low prevalence of sexual abuse (2 of 31 children) found in this study suggest innocent auto- or heteroinoculation from cutaneous warts may be a common means by which children acquire AG warts.<p /> <p>Language: en</p>
LA  - en
SN  - 0736-8046
UR  - http://dx.doi.org/
ID  - ref1
ER  -