TY  - JOUR
PY  - 1997//
TI  - Prolonged treatment with beta-adrenoceptor antagonists counteracts the aggression deficit induced by chronic stress
JO  - Polish journal of pharmacology
A1  - Zebrowska-Lupina, I.
A1  - Ossowska, G.
A1  - Lupina, T.
A1  - Klenk-Majewska, B.
SP  - 283
EP  - 289
VL  - 49
IS  - 5
N2  - Chronic stress-induced behavioral disturbances have been used as experimental models of depression. One of them is the deficit of fighting behavior induced by 16-day application of various unpredictable stressors. In the present study we investigated the effect of beta-adrenoceptor antagonists (propranolol, pindolol, nadolol and acebutolol) on electric footshock-induced fighting behavior in chronically stressed (14 various stressors over 16 days) male Wistar rats. It was found that the number of fighting attacks was reduced by about 50-80% in the rats submitted to chronic stress. Prolonged, 14-day, but not acute, treatment with propranolol, pindolol or nadolol (but not acebutolol) counteracted the deficit of aggression induced by chronic stress. It is suggested that beta-adrenoceptor antagonists which penetrate the blood-brain barrier may prevent the behavioral changes induced by chronic stress.<p /> <p>Language: en</p>
LA  - en
SN  - 1230-6002
UR  - http://dx.doi.org/
ID  - ref1
ER  -