TY  - JOUR
PY  - 1997//
TI  - Ethanol and pentobarbital: comparison of behavioral and subjective effects in sedative drug abusers
JO  - Experimental and clinical psychopharmacology
A1  - Mintzer, M. Z.
A1  - Guarino, J.
A1  - Kirk, T.
A1  - Roache, John D.
A1  - Griffiths, Roland R.
SP  - 203
EP  - 215
VL  - 5
IS  - 3
N2  - The behavioral and subjective effects of acute oral doses of placebo, ethanol (0.5, 1.0, and 2.0 g/kg), and pentobarbital (150, 300, 600, and 750 mg/70 kg) were compared in 8 male volunteers with histories of sedative drug abuse using a double-blind, double-dummy, cross-over design. Ethanol and pentobarbital produced similar dose-related decrements in psychomotor and cognitive performance and exhibited a similar profile of effects on staff- and participant-rated measures. There was some evidence indicating that, at the highest dose, pentobarbital was perceived by participants as being more sedating than ethanol and that pentobarbital has a greater abuse liability than ethanol. In conjunction with the results of previous human laboratory studies comparing the effects of different types of sedative-hypnotic drugs, these results support a mostly barbiturate-like rather than benzodiazepine-like profile of effects for ethanol.<p /> <p>Language: en</p>
LA  - en
SN  - 1064-1297
UR  - http://dx.doi.org/
ID  - ref1
ER  -