TY - JOUR PY - 1997// TI - Neurochemical changes and current pharmacological approaches in craniocerebral trauma JO - Unfallchirurg A1 - Kossmann, T. A1 - Lenzlinger, P. M. A1 - Stover, J. F. A1 - Stocker, R. A1 - Morganti-Kossmann, M. C. A1 - Trentz, O. SP - 613 EP - 622 VL - 100 IS - 8 N2 - In recent years, our knowledge concerning pathophysiological changes in brain metabolism after traumatic brain injury (TBI) has greatly expanded. This, in turn, has enabled the development of specific pharmacological strategies for the supplementary treatment of brain-injured patients with the aim of reducing secondary brain damage. The present article focuses on the pathophysiology of TBI and the possibilities for pharmacological intervention. While some of the substances reviewed and presently used in the treatment of TBI, others are under experimental and clinical evaluation at different stages.
Language: de
LA - de SN - 0177-5537 UR - http://dx.doi.org/ ID - ref1 ER -