TY  - JOUR
PY  - 1997//
TI  - Serotonergic function and self-injurious behavior in personality disorder patients
JO  - Psychiatry research
A1  - New, A. S.
A1  - Trestman, R. L.
A1  - Mitropoulou, V.
A1  - Benishay, D. S.
A1  - Coccaro, E.
A1  - Silverman, Jay G.
A1  - Siever, Larry J.
SP  - 17
EP  - 26
VL  - 69
IS  - 1
N2  - Self-directed aggression, whether in the form of non-suicidal self-mutilation or suicidal behavior, is a prominent feature of personality disorders. We hypothesized that self-injurious behavior, like suicidal behavior, represents a form of self-directed aggression, and may, like suicidal behavior and impulsive aggression, be associated with a decrease in central serotonin function in personality disorder patients. Ninety-seven patients with DSM-III personality disorder underwent D,L-fenfluramine challenge as an assessment of serotonergic activity. Patients with a history of self-mutilation or suicide had blunted prolactin and cortisol responses to D,L-fenfluramine compared to those with neither, and those with both had the most blunted responses to fenfluramine. These data raise the possibility that the central 5-HT abnormality, previously associated with suicidal behavior, may be associated with self-directed violence and not necessarily specifically with suicidal intent.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/
ID  - ref1
ER  -