TY  - JOUR
PY  - 1994//
TI  - NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms
JO  - European Neuropsychopharmacology
A1  - Sabatino, M.
A1  - Cannizzaro, C.
A1  - Flugy, A.
A1  - Gagliand, M.
A1  - Mineo, A.
A1  - Cannizzaro, G.
SP  - 103
EP  - 109
VL  - 4
IS  - 2
N2  - We studied the effects of desipramine, alprazolam, muscimol and dizocilpine (MK-801) (alone or associated with desipramine) in the forced swimming test in rats after long-lasting termination of chronic exposure to vehicle and pentylenetetrazol. Sensitisation with pentylenetetrazol was ineffective in changing immobility time in the forced swimming test compared to vehicle treatment; pentylenetetrazol enhanced the anti-immobility effect of desipramine, abolished the anti-immobility effect of alprazolam and did not affect the anti-immobility effect of muscimol. MK-801 at the dose that did not modify immobility time in vehicle-treated rats and in pentylenetetrazol-treated animals strongly potentiated the anti-immobility effect of desipramine in pentylenetetrazol-treated rats. MK-801 in association with desipramine induced a marked hyperlocomotion and hyperexcitability, with swaying movements and oral stereotypies in pentylenetetrazol-sensitised rats. Results are considered the experimental representation of a 'gating mechanism' toward psychotic-like symptoms.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/
ID  - ref1
ER  -