TY  - JOUR
PY  - 2006//
TI  - Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks
JO  - Depression and anxiety
A1  - Dougherty, Darin D.
A1  - Bonab, Ali A.
A1  - Ottowitz, William E.
A1  - Livni, Eli
A1  - Alpert, Nathaniel M.
A1  - Rauch, Scott L.
A1  - Fava, Maurizio
A1  - Fischman, Alan J.
SP  - 175
EP  - 177
VL  - 23
IS  - 3
N2  - This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression.<p /> <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.20168
ID  - ref1
ER  -