TY  - JOUR
PY  - 2001//
TI  - Suppressing aggressive behavior with analogs of allopregnanolone (epalon)
JO  - Steroids
A1  - Slavíková, B.
A1  - Kasal, A.
A1  - Uhlírová, L.
A1  - Krsiak, M.
A1  - Chodounská, H.
A1  - Kohout, L.
SP  - 99
EP  - 105
VL  - 66
IS  - 2
N2  - 3alpha-Hydroxy-20-oxo-5alpha-pregnan-21-yl hemisuccinate (8) was produced by partial acylation of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (14). 3alpha-Fluoro-5alpha-pregnan-20-one (9) was prepared by treatment of 3beta-hydroxy-5alpha-pregnan-20-one (11) with DAST and by solvolysis of tosylate 12 with tetrabutylammonium fluoride. A behavioral test on mice was performed using 3alpha-hydroxy-5alpha-pregnan-20-one (1) and compounds 8 and 9. Compound 8 was found to be inactive, while the fluoro derivative 9 selectively reduced aggressive behavior in mice more than the corresponding 3alpha-hydroxy compound 1; locomotion and other behavioral features were not affected.<p /> <p>Language: en</p>
LA  - en
SN  - 0039-128X
UR  - http://dx.doi.org/
ID  - ref1
ER  -