TY  - JOUR
PY  - 2001//
TI  - Participation of 5-HT1A-receptors in regulating various types of aggressive behavior
JO  - Zhurnal vyssheĭ nervnoĭ deyatelnosti imeni I P Pavlova
A1  - Vishnivetskaia, G. B.
A1  - Pliusnina, I. Z.
A1  - Popova, N. K.
SP  - 704
EP  - 708
VL  - 51
IS  - 6
N2  - We studied the effects of selective agonists of 5-HT1A receptors 8-OH-DPAT and flesinoxan on aggressive behavior of C57BL/6 male mice in the "resident-intruder" test and on defensive aggression of Norway rats toward man. 8-OH-DPAT (0.4 mg/kg, i.p.) significantly reduced the intermale aggression in mice and defensive aggression in rats (0.1-0.5 mg/kg, i.p.). In the dose of 0.5 mg/kg, flesinoxan inhibited the aggressive behavior in mice. These results suggest that activation of 5-HT1A receptors reduces different kinds of affective aggression. The results are discussed in terms of interaction between the well-known anxiolytic effects of 5-HT1A agonists and their antiaggressive properties.<p /> <p>Language: ru</p>
LA  - ru
SN  - 0044-4677
UR  - http://dx.doi.org/
ID  - ref1
ER  -