TY  - JOUR
PY  - 2004//
TI  - Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats
JO  - Behavioral neuroscience
A1  - Kalynchuk, Lisa E.
A1  - Gregus, Andrea
A1  - Boudreau, Daniel
A1  - Perrot-Sinal, Tara S.
SP  - 1365
EP  - 1377
VL  - 118
IS  - 6
N2  - This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats. Rats received either corticosterone or vehicle injections for 21 consecutive days prior to behavioral testing in the forced swim, open-field, and predator odor tests. The corticosterone injections significantly increased depression-like behavior in the forced swim test in both male and female rats but had no significant effect on anxiety in the open-field test. In the predator odor test, the corticosterone injections significantly increased a subset of defensive behaviors in the male rats. These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation.<p /> <p>Language: en</p>
LA  - en
SN  - 0735-7044
UR  - http://dx.doi.org/10.1037/0735-7044.118.6.1365
ID  - ref1
ER  -