TY  - JOUR
PY  - 2002//
TI  - A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients
JO  - American journal of medical genetics
A1  - Staner, Luc
A1  - Uyanik, Gökhan
A1  - Correa, Humberto
A1  - Tremeau, Fabien
A1  - Monreal, José
A1  - Crocq, Marc-Antoine
A1  - Stefos, Grigori
A1  - Morris-Rosendahl, Deborah J.
A1  - Macher, Jean Paul
SP  - 553
EP  - 557
VL  - 114
IS  - 5
N2  - Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin, and association and linkage studies of its variants in suicidal and impulsive-aggressive behavior have brought conflicting results. This pilot study was designed to investigate whether TPH A218C genotypes could be associated with impulsive behavioral tendencies (IBTs) in consecutively admitted nonpsychotic nonorganic inpatients. Patients (20 females and 34 males; age, 38.8 +/- 11.8) did not differ from healthy nonimpulsive controls (16 females and 11 males; age, 35.2 +/- 10.2) regarding TPH genotypes, but in the patients, the number of IBT was related to the presence of the 218C allele. It was concluded that impulsive-aggressive behavior may be associated with the TPH genotype in well-characterized impulsive patients and that the present results stress the importance of considering impulsiveness-aggressiveness in studies investigating the relationship between suicidal behavior and TPH genotypes.<p /> <p>Language: en</p>
LA  - en
SN  - 0148-7299
UR  - http://dx.doi.org/10.1002/ajmg.10405
ID  - ref1
ER  -