TY  - JOUR
PY  - 2007//
TI  - Tolerability of selective serotonin reuptake inhibitors in thirty-nine children under age seven: a retrospective chart review
JO  - Journal of child and adolescent psychopharmacology
A1  - Zuckerman, Marcia L.
A1  - Vaughan, Brigid L.
A1  - Whitney, Jane
A1  - Dodds, Alice
A1  - Yakhkind, Aleksandra
A1  - MacMillan, Carlene
A1  - Raches, Darcy
A1  - Pravdova, Iva
A1  - Demaso, David Ray
A1  - Beardslee, William R.
A1  - Gonzalez-Heydrich, Joseph
SP  - 165
EP  - 174
VL  - 17
IS  - 2
N2  - OBJECTIVE: To characterize the adverse effects of treatment with selective serotonin reuptake inhibitors (SSRIs) started in children under age 7 yr. METHODS: We conducted a retrospective review of medical records for all children who had begun treatment with an SSRI under age 7 at an academic psychiatry department in Boston. RESULTS: Thirty-nine children (26 males, 13 females) met the inclusion criteria. Mean age at start of treatment was 5.9 +/- 0.8 yr, and median treatment duration was 5.0 months. The target diagnoses for SSRI treatment were anxiety disorders in 54%, depressive disorders in 23%, and both anxiety and depressive disorders in 20% of patients. There were no reports of suicidal ideation or attempt. No children were medically or psychiatrically hospitalized for adverse effects (AEs). Eleven patients (28%) reported an AE of at least moderate severity; 7 (18%) discontinued the SSRI due to the AE. Six patients discontinued due to behavioral activation and 1 due to gastrointestinal upset. The median time to onset of an AE was 23 days, and median resolution was 19 days from onset. CONCLUSIONS: The high rate of adverse effects, especially activation, in this sample argues for continued caution in using SSRIs in young children. Controlled trials are warranted.<p /> <p>Language: en</p>
LA  - en
SN  - 1044-5463
UR  - http://dx.doi.org/10.1089/cap.2007.0086
ID  - ref1
ER  -