TY  - JOUR
PY  - 2007//
TI  - Response inhibition in psychopathy: the frontal N2 and P3
JO  - Neuroscience letters
A1  - Munro, Gillian E. S.
A1  - Dywan, Jane
A1  - Harris, Grant T.
A1  - McKee, Shari
A1  - Unsal, Ayse
A1  - Segalowitz, Sidney J.
SP  - 149
EP  - 153
VL  - 418
IS  - 2
N2  - Psychopathy has been associated with atypical function of the anterior cingulate cortex (ACC) and adjacent brain regions and with abnormalities in performance monitoring, which is thought to rely on these structures. The ACC and adjacent regions are also involved in the generation of two characteristic components of the event-related potential: the frontal N2 and P3. Both components are enhanced when a response is withheld (NoGo trial) within a series of positive-responses (Go trials) and are considered an index of response inhibition. We recorded event-related potentials while violent offenders who varied on the dimension of psychopathy and non-offender controls performed a Go/NoGo task. The offenders made more errors of commission on NoGo trials but this effect was unrelated to level of psychopathy within the group and, inconsistent with a previous report, they produced the enhanced frontal N2 and P3 effect in response to NoGo relative to Go conditions. We conclude that the neural processes involved in response inhibition are not abnormal in psychopaths when both stimuli and context are affectively neutral and suggest that a more nuanced perspective regarding impulsivity in this population be considered.<p /> <p>Language: en</p>
LA  - en
SN  - 0304-3940
UR  - http://dx.doi.org/10.1016/j.neulet.2007.03.017
ID  - ref1
ER  -