TY  - JOUR
PY  - 2003//
TI  - Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
JO  - Science
A1  - Caspi, Avshalom
A1  - Sugden, Karen
A1  - Moffitt, Terrie E.
A1  - Taylor, Alan
A1  - Craig, Ian W.
A1  - Harrington, HonaLee
A1  - McClay, Joseph
A1  - Mill, Jonathan
A1  - Martin, Judy
A1  - Braithwaite, Antony
A1  - Poulton, Richie
SP  - 386
EP  - 389
VL  - 301
IS  - 5631
N2  - In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.<p /> <p>Language: en</p>
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/10.1126/science.1083968
ID  - ref1
ER  -