TY  - JOUR
PY  - 2003//
TI  - Aggression: the testosterone-serotonin link
JO  - Israel medical association journal : IMAJ
A1  - Birger, Moshe
A1  - Swartz, Marnina
A1  - Cohen, David
A1  - Alesh, Ya'akov
A1  - Grishpan, Chaim
A1  - Kotelr, Moshe
SP  - 653
EP  - 658
VL  - 5
IS  - 9
N2  - The relevance of central neurotransmission to aggressive and impulsive behavior has become more evident due to extensive research in humans and animals. Among other findings, there are abundant data relating low serotonergic activity--as measured by low cerebrospinal fluid 5-hydroxyindolacetic acid, and a blunted response of prolactin to fenfluramine--to impulsive behavior. Many studies on testosterone activity show a relation between high plasma levels and a tendency towards aggression. It is hypothesized that the interaction between low serotonin and high testosterone levels in the central nervous system has a significant effect on the neural mechanisms involved in the expression of aggressive behavior. It seems that testosterone modulates serotonergic receptor activity in a way that directly affects aggression, fear and anxiety. Our survey reviews the main findings on serotonin, testosterone and the possible interaction between them with regard to these behavioral phenomena.<p /> <p>Language: en</p>
LA  - en
SN  - 1565-1088
UR  - http://dx.doi.org/
ID  - ref1
ER  -