TY  - JOUR
PY  - 2000//
TI  - Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats
JO  - Methods and findings in experimental and clinical pharmacology
A1  - Rudissaar, R.
A1  - Pruus, K.
A1  - Skrebuhhova-Malmros, T.
A1  - Allikmets, L.
A1  - Matto, V.
SP  - 637
EP  - 640
VL  - 22
IS  - 8
N2  - The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0355
UR  - http://dx.doi.org/
ID  - ref1
ER  -