TY  - JOUR
PY  - 2000//
TI  - The serotonin 5-HT(2A) receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wistar rats
JO  - Pharmacology, biochemistry, and behavior
A1  - Skrebuhhova-Malmros, T.
A1  - Pruus, K.
A1  - Rudissaar, R.
A1  - Allikmets, L.
A1  - Matto, V.
SP  - 339
EP  - 343
VL  - 67
IS  - 2
N2  - We have studied the effect of the 5-HT(2A) receptor antagonists on apomorphine-induced aggressive behaviour in male Wistar rats. In acute behavioural experiments with apomorphine-pretreated (1.0 mg/kg, s.c., once daily, 2 weeks) animals, risperidone (0.5 and 1.0 mg/kg) inhibited aggressive behaviour, but ketanserin and ritanserin (0.5-5. 0 mg/kg) had no effect on the latency and intensity of aggressive behaviour. Concomitant risperidone (0.5 mg/kg) and haloperidol (0.03 and 0.3 mg/kg) administration blocked aggressive behaviour completely. In conclusion, our experiments confirm that inhibition of the apomorphine-induced aggressive behaviour is elicited by drugs with dopamine (DA) but not with 5-HT(2A) antagonistic activity. Moreover, it may be concluded that the serotonin 5-HT(2A) receptor subtype does not alter the DA-mediated behaviour.<p /> <p>Language: en</p>
LA  - en
SN  - 0091-3057
UR  - http://dx.doi.org/
ID  - ref1
ER  -