TY  - JOUR
PY  - 2000//
TI  - Naloxone-induced opiate withdrawal produces long-lasting and context-independent changes in aggressive and social behaviors of postdependent male mice
JO  - Behavioral neuroscience
A1  - Felip, C. M.
A1  - Rodríguez-Arias, M.
A1  - Espejo, E. F.
A1  - Miñarro, J.
A1  - Stinus, L.
SP  - 424
EP  - 430
VL  - 114
IS  - 2
N2  - The purpose of this study was to determine whether an environment associated with naloxone-induced morphine withdrawal affects aggressive or social behaviors in postdependent mice. Morphine-dependent or saline-treated mice received 3 naloxone injections in 1 of 2 different environments (A or B); 15 days afterward, when the mice were completely drug free, an aggression test was carried out in Environment A. All the mice suffering morphine withdrawal showed a significant increase in aggression, irrespective of the environment in which the withdrawal took place. In these conditions, the impact of morphine dependence and the 3 induced withdrawals was so profound that the environment could not be discriminative. In addition, modifications in the behavioral profile of postdependent mice that suffered only spontaneous withdrawal were long-lasting, with the mice carrying out more attacks during social investigation without presenting threat postures.<p /> <p>Language: en</p>
LA  - en
SN  - 0735-7044
UR  - http://dx.doi.org/
ID  - ref1
ER  -