TY  - JOUR
PY  - 2000//
TI  - Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders
JO  - Biological psychiatry
A1  - Bellivier, F.
A1  - Szöke, A.
A1  - Henry, C.
A1  - Lacoste, J.
A1  - Bottos, C.
A1  - Nosten-Bertrand, M.
A1  - Hardy, P.
A1  - Rouillon, Frédéric
A1  - Launay, J. M.
A1  - Laplanche, J. L.
A1  - Leboyer, M.
SP  - 319
EP  - 322
VL  - 48
IS  - 4
N2  - BACKGROUND: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case-control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior. METHODS: A functional polymorphism of the 5-HTT gene (a 44-base pair insertion/deletion in the 5-HTT-linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt. RESULTS: No association was found between the "s" allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects. CONCLUSIONS: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/
ID  - ref1
ER  -