TY  - JOUR
PY  - 2000//
TI  - Ethanol modulates evoked dopamine release in mouse nucleus accumbens: dependence on social stress and dose
JO  - European journal of pharmacology
A1  - Yavich, L.
A1  - Tiihonen, Jari
SP  - 365
EP  - 373
VL  - 401
IS  - 3
N2  - Ethanol may modulate the activity of presynaptic terminals to increase extracellular dopamine release in the nucleus accumbens though conflicting results have been published. It has been suggested that the stress of social defeat might be a factor influencing the effects of ethanol. We investigated the effects of ethanol on the evoked dopamine overflow in the nucleus accumbens in anaesthetised mice by in vivo voltammetry. Dominant animals, subordinates which had been defeated following eight intruder-resident encounters, and subordinate nondefeated mice were used. The overflow was evoked by electrical stimulation of the median forebrain bundle (100 pulses) at low (20 Hz) and high (50 Hz) frequencies of stimulation. Ethanol at 0.1 and 2 g/kg had no effects on evoked dopamine overflow in aggressive and nondefeated mice. Ethanol increased dopamine release at 0.1 g/kg and decreased release at 2 g/kg following high frequency stimulation in defeated mice. These data suggest that the stress of social defeat may have sensitised the machinery involved in dopamine release to ethanol, a process that may increase the reinforcing properties of this compound.<p /> <p>Language: en</p>
LA  - en
SN  - 0014-2999
UR  - http://dx.doi.org/
ID  - ref1
ER  -