TY  - JOUR
PY  - 1990//
TI  - Synthesis and properties of the derivatives of 2-alkylthio-4-oxo-3,4- (and -1,4)-dihydropyrido-[2,3-d]pyrimidine-5- and -6-carboxylic acids
JO  - Farmaco (Società chimica italiana : 1989)
A1  - Sladowska, H.
A1  - Bartoszko-Malik, A.
A1  - Zawisza, T.
SP  - 111
EP  - 121
VL  - 45
IS  - 1
N2  - Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (I) with the corresponding isothiocyanates afforded derivatives of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylate (V-VII). Alkylation of (V), (VI) and (XI) gave the corresponding derivatives of ethyl 2-alkylthio-4-oxo-3,4-(and 1,4)-dihydropyrido[2,3-d]pyrimidine-5- and -6- carboxylate [(XII-XVI), (XX-XXII)]. Some of the obtained compounds were active pharmacologically.<p /> <p>Language: en</p>
LA  - en
SN  - 0014-827X
UR  - http://dx.doi.org/
ID  - ref1
ER  -