TY  - JOUR
PY  - 2008//
TI  - Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls
JO  - European Neuropsychopharmacology
A1  - Sher, Leo
A1  - Stanley, Barbara H.
A1  - Cooper, Thomas B.
A1  - Malone, Kevin M.
A1  - Mann, J. John
A1  - Oquendo, Maria A.
SP  - 692
EP  - 699
VL  - 18
IS  - 9
N2  - Dysfunction of serotonergic neurotransmission has been implicated in the etiopathogenesis of major depression (MDD) and alcohol use disorders (AUD). To compare serotonin function in MDD with co-occurring AUD (MDD/AUD), MDD without co-occurring AUD (MDD only) and healthy controls (HC) we sought to study differences in prolactin responses to fenfluramine administration in patients with MDD/AUD, patients with MDD only and HC. In all, 169 subjects (62 MDD/AUD, 75 MDD only, and 32 HC) were entered into the study. Controlling for gender, prolactin responses were lower in the MDD/AUD group compared to the MDD only or the HC group. Controlling for gender and aggression, prolactin responses in the MDD/AUD group remained significantly lower compared to the HC group but the difference between the MDD/AUD and the MDD only groups disappeared. The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2008.05.005
ID  - ref1
ER  -