TY  - JOUR
PY  - 2008//
TI  - Methylphenidate in children with oppositional defiant disorder and both comorbid chronic multiple tic disorder and ADHD
JO  - Journal of child neurology
A1  - Gadow, Kenneth D.
A1  - Nolan, Edith E.
A1  - Sverd, Jeffrey
A1  - Sprafkin, Joyce
A1  - Schneider, Jayne
SP  - 981
EP  - 990
VL  - 23
IS  - 9
N2  - Our primary objective was to determine if immediate-release methylphenidate is an effective treatment for oppositional defiant disorder diagnosed from mother's report in children with both chronic multiple tic disorder and attention-deficit hyperactivity disorder (ADHD). Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and were assessed with ratings scales and laboratory measures. Results indicated significant improvement in both oppositional and ADHD behaviors with medication; however, the magnitude of treatment effect varied considerably as a function of disorder (ADHD > Oppositional behaviors), informant (teacher > mother), assessment instrument, and specific oppositional behavior (rebellious > disobeys rules). Drug response was comparable with that in children (n = 26) who did not have diagnosed oppositional defiant disorder, but comorbidity appeared to alter the perceived benefits for ADHD according to mother's report. Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder.<p /> <p>Language: en</p>
LA  - en
SN  - 0883-0738
UR  - http://dx.doi.org/10.1177/0883073808315412
ID  - ref1
ER  -