TY  - JOUR
PY  - 2008//
TI  - Effect of memantine treatment on patients with moderate-to-severe Alzheimer's disease treated with donepezil
JO  - Revista medico-chirurgicală a Societă ţ̜ii de Medici şi Naturalişti din Iaşi
A1  - Creţu, Oana
A1  - Szalontay, Andreea Silvana
A1  - Chiriţă, Roxana
A1  - Chiriţă, V.
SP  - 641
EP  - 645
VL  - 112
IS  - 3
N2  - OBJECTIVE: Investigating the behavioral and cognitive effect of memantine in moderate to severe patients with Alzheimer's disease receiving donepezil. MATERIAL AND METHOD: 43 patients were enrolled in this prospective, randomized, parallel group study. There were no significant imbalances between the treatment groups in demographic and baseline clinical characteristics. Cognitive and global measures were collected at baseline and at the end of weeks 4, 8, 12 and 24. Behavioral measures were collected at baseline, at the end of week 12 and at week 24. RESULTS: Memantine--treated patients showed significantly less deterioration in their functionality. Of patients who exhibited agitation/aggression at baseline, those treated with memantine and donepezil showed significant reduction of symptoms compared with donepezil--treated patients. CONCLUSIONS: Treatment with memantine was well tolerated and reduced agitation/aggression, irritability, and appetite eating disturbances in patients who were agitated at baseline and delazed its emergence in those who were free of agitation at baseline.<p /> <p>Language: ro</p>
LA  - ro
SN  - 0048-7848
UR  - http://dx.doi.org/
ID  - ref1
ER  -