TY  - JOUR
PY  - 2008//
TI  - Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population
JO  - European Neuropsychopharmacology
A1  - Kim, Youl-Ri
A1  - Kim, Jeong Hyun
A1  - Kim, Se Joo
A1  - Lee, Dongeun
A1  - Min, Sung Kil
SP  - 820
EP  - 825
VL  - 18
IS  - 11
N2  - We examined the association between the Catechol-O-methyltransferase (COMT) Val158Met polymorphism and aggressive schizophrenia. The sample included 61 aggressive schizophrenic patients as well as 104 non-aggressive patients from psychiatric hospitals and 415 healthy volunteers in South Korea. In the case-control comparisons, there was no significant association between the aggressive schizophrenic patients and the COMT Val158Met polymorphism. Looking only at the subgroup of aggressive schizophrenic patients, however, we found a dose-dependent relationship between the Met allele and verbal aggression. In this subgroup, the Met carriers showed a higher verbal aggression score than those with the Val/Val homozygote. These findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMT Val158Met polymorphism and aggressive schizophrenia case status in the Korean population.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2008.07.009
ID  - ref1
ER  -